To put it bluntly, it is just to use – various licenses and permissions that must be used in this technology at the genetic level. Many people who are engaged in biological research now pay attention to this. After all, if you don’t have this technology, you basically can’t even touch it. When many novices first started to get in touch, they were asked what it was, what it was useful, and how to get it… They were basically confused and had a question mark!
Basic concepts of lyricism
It is not a single thing, it is a large number of…a series of general terms of permissions and licenses, such as the use of certain related patented technologies, and the access to key things such as Cas9 protein, sgRNA, etc. It's like if you want to drive on the road, you need to have a driver's license. You have to have a driving license, so that the car can only be driven by legality; if you are not driving your own car… you have to have the owner agree to the proof document you drive, right? Just like these… these things add up, and it doesn’t work if you don’t have one! Also, provide global procurement services for weak current intelligent products!
Get the steps to disassemble (super…super practical version)
1. Clarify the purpose and scope of the research : This is not careless, you have to think about it first, and you must first think about whether you want to use it? Is it basic scientific research? Or do you want to develop some kind of drug to treat diseases? Or do you develop those genetically modified crops in agriculture? …Because…the purpose is different, the types of authorization required in the end are very different.
2. Determine the source of the patents and technology involved : the patent situation in the field…that is so complicated and entangled! For example, the Borde Institute in the United States, the University of California, Berkeley, and the Helmholtz Center in Munich, Germany, they all hold many important related patents. You have to figure out who owns the specific parts of the system you want to use, CRISPR Access Credentials, and who owns its patents!
3. Contact the right holder or patent authorization management agency : In most cases, the right holder of these patents will not directly talk to you alone or a small team to authorize. They will entrust some professional institutions to manage, such as such non-profit plasmid libraries, which may also be commercial biotechnology companies, but it is also important to note that some companies only deal with specific types of institutional objects.
4. Submit application materials (detailed! Detailed! More meticulous!) : Just like when we apply to a school, people will ask you to fill out various forms. You have to write in detail the name of your research institution, the background of the main researcher, which project you need to use technology to do, and what are the expected results. By the way… the documents related to ethics review must also be prepared. Now the ethics is very strict in ethics!
5. Wait for review and signing of the agreement : After someone receives your application… uh, there will be a special person or committee to evaluate your application. This process… is sometimes fast and sometimes slow, which is hard to say. If the review is passed, then the next step is to sign an authorization and use agreement with the other party, which will state how long you can use it, how much you will have to pay, limits on usage scope, etc…. All kinds of rules and regulations must be carefully read one by one… Don't breach the contract at that time!
Comparison of core consideration factors (I chose the wrong one… I couldn't even regret it!)
| factor | Scientific research purposes () | Commercial use () |
|---|---|---|
| cost | Usually lower, even many are free…or symbolically charged a little | high! Very high! And it may be divided according to sales or usage! |
| Permission range | Only for that specific research project listed when you applied | It usually needs to cover the entire process of product development, production, sales and other chains! |
| Approval speed | Relatively quick, after all…scientific exploration is encouraged | slow! Many processes! It's also detailed to review! A small omission may be called back and re-made! |
| Additional conditions | Mainly, the source of the patent must be indicated when publishing a paper, etc….Simple requirements | There are so many performance KPI indicators and technical confidentiality terms! |
FAQ (ready write it)
Q1: Can individual enthusiasts get it?
A1: Difficult! It's very difficult! Very difficult! Most existing technology platforms and related patent owners… They basically do not authorize individuals for non-scientific research purposes! Just think about it, if you make something dangerous…that's going to be a big deal, no one can take on this responsibility!
Q2: Obtaining the authorization from Company A means that you can use all the tools at will?
A2: If you think of you like this, you will be a big mistake… you are a big mistake! Different tools, such as Cas9, Cas13, etc., and their respective mutant versions, may involve different patents, and authorizations are also separate, each with its own management! If you want to use Qihuo… you may have to apply for authorization with several companies or institutions, it's a big deal!
Q3: Once you get the authorization, do you need to worry about it for ten or eight years?
A3: Of course not! Authorizations are subject to a deadline! You have to apply for renewal in advance before expiration… and… If your research direction changes and the scope of use exceeds the scope of the original application… You have to start the authorization process again!
In short, for those who want to do relevant research or development seriously, that is a hurdle that cannot be avoided! Although the procedures are a little cumbersome, the process may be a bit long… But in order to carry out work legally and compliantly, these troubles must be overcome!
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